KL↗The Inventor IslandWoody Lin · PhD

THE CAPABILITIES BEHIND THE DISCOVERIES

Scientific judgment,
supported by technical depth.

01

AI & technology evaluation

Find capabilities beyond a model’s original objective. Test predictions, understand limitations, and define the evidence needed for adoption.

02

Computational biology

Connect RNA biology, functional genomics, and multi-omics to explain disease mechanisms and generate testable hypotheses.

03

Drug discovery strategy

Translate molecular and clinical evidence into target prioritization, patient-stratification hypotheses, and the next experiment.

04

Discovery from limited patient data

Extract useful biological signals from sparse or challenging clinical material, then strengthen the interpretation with independent evidence.

05

Scientific leadership & platforms

Build computational functions and reproducible workflows. Bring computational, experimental, and leadership teams to a shared scientific decision.

BUILDING WHAT THE QUESTION NEEDS

When the method is missing,
develop it.

PSI-SIGMA · BIOINFORMATICS 2019

Making RNA differences easier to detect

I designed and implemented PSI-Sigma to analyze alternative splicing using short- and long-read RNA sequencing. Developing a reusable method makes a way of seeing biology available to other researchers.

Value: a published analytical tool that supports further discovery.

Read the method ↗

SMN2 · NUCLEIC ACIDS RESEARCH 2022

Connecting sequence changes to therapeutic design

My analysis of minigene experiments mapped elements controlling SMN2 splicing, including previously uncharacterized elements. The work connected experimental measurements to a biological question relevant to antisense-oligonucleotide design.

Read the study ↗
Technical foundation

Python, Perl, C/C++, JavaScript, Linux/Unix, AWS, Nextflow, RNA-seq, NGS, and multi-omics analysis.

BACKGROUND

Scientific depth.
A broader perspective.

Across academic research and biotechnology, I have repeatedly worked at the boundary of what our tools can reveal.

I work across computational and experimental disciplines, helping teams turn complex findings into clear scientific recommendations. My PhD in Biomedical Informatics and MBA in Management Information Systems inform both the technical work and the decisions around it.

Education

PhD, Biomedical Informatics
National Yang-Ming University · 2009–2013

MBA, Management Information Systems
West Texas A&M University · 2004–2005

  1. 2023–2026

    Codify Therapeutics

    Associate Director, Bioinformatics

  2. 2020–2023

    Skyhawk Therapeutics

    Principal Scientist, Bioinformatics & Machine Learning

  3. 2015–2022

    Cold Spring Harbor Laboratory

    Adrian R. Krainer Lab
    Computational Postdoc, 2015–2020
    Visiting Scientist, 2020–2022

  4. 2006–2015

    Early research in Taiwan

    Research roles at Taipei Medical University, National Yang-Ming University, and Academia Sinica

INVENTION
Co-inventor, US10953059B2
Methods and compositions for treating non-small cell lung cancer

RECOGNITION
SOAR Award, Skyhawk Therapeutics
2021

SELECTED TALKS
National Academies, 2023
London Calling, Oxford Nanopore, 2019

THE PUBLISHED RECORD

A record of
collaborative discovery.

2025
CellCo-author

Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias

2023
NatureSecond author

RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer

2023
Cancer DiscoverySecond author

Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer

2022
Nucleic Acids ResearchCo-first author

Splicing-regulatory elements in SMA

2019
NatureCo-first author

Coordinated alterations in RNA splicing and epigenetic regulation drive leukemogenesis

2019
BioinformaticsFirst author

PSI-Sigma: a splicing detection tool for short and long reads

2018
Genome ResearchFirst author

AFMID splicing in hepatocellular carcinoma

2014
OncogeneCo-first author

Identification of latent biomarkers in hepatocellular carcinoma by ultra-deep whole-transcriptome sequencing

2014
Journal of Proteome ResearchCo-first author

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

Selected collaborative research. Labels show my authorship position; co-first denotes a shared-first contribution. Some titles are abbreviated for readability.

Full publication bibliography ↗